MONACOLIN K
\mˈɒnɐkˌɒlɪn kˈe͡ɪ], \mˈɒnɐkˌɒlɪn kˈeɪ], \m_ˈɒ_n_ɐ_k_ˌɒ_l_ɪ_n k_ˈeɪ]\
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A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
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