MIXED OLIGODENDROGLIOMA ASTROCYTOMAS
\mˈɪkst ˌɒlɪɡˌə͡ʊdəndɹˌɒɡlɪˈə͡ʊməɹ ˌastɹəsɪtˈə͡ʊməz], \mˈɪkst ˌɒlɪɡˌəʊdəndɹˌɒɡlɪˈəʊməɹ ˌastɹəsɪtˈəʊməz], \m_ˈɪ_k_s_t ˌɒ_l_ɪ_ɡ_ˌəʊ_d_ə_n_d_ɹ_ˌɒ_ɡ_l_ɪ__ˈəʊ_m_ə_ɹ ˌa_s_t_ɹ_ə_s_ɪ_t_ˈəʊ_m_ə_z]\
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A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.