LUPUS COAGULATION INHIBITOR
\lˈuːpəs kə͡ʊˌaɡjʊlˈe͡ɪʃən ɪnhˈɪbɪtə], \lˈuːpəs kəʊˌaɡjʊlˈeɪʃən ɪnhˈɪbɪtə], \l_ˈuː_p_ə_s k_əʊ_ˌa_ɡ_j_ʊ_l_ˈeɪ_ʃ_ə_n ɪ_n_h_ˈɪ_b_ɪ_t_ə]\
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An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC), ANTIPHOSPHOLIPID SYNDROME, and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.
By DataStellar Co., Ltd
