L THR L LYS L PRO L ARG
\ˈɛl tˌiːˌe͡ɪt͡ʃˈɑːɹ ˈɛl lˈa͡ɪz ˈɛl pɹˈə͡ʊ ˈɛl ˈɑːɡ], \ˈɛl tˌiːˌeɪtʃˈɑːɹ ˈɛl lˈaɪz ˈɛl pɹˈəʊ ˈɛl ˈɑːɡ], \ˈɛ_l t_ˌiː__ˌeɪ_tʃ_ˈɑː_ɹ ˈɛ_l l_ˈaɪ_z ˈɛ_l p_ɹ_ˈəʊ ˈɛ_l ˈɑː_ɡ]\
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N (2)- ( (1- (N (2)-L-Threonyl)-L-lysyl)-L-prolyl)-L-arginine. A tetrapeptide produced in the spleen by enzymatic cleavage of a leukophilic gamma-globulin. It stimulates the phagocytic activity of blood polymorphonuclear leukocytes and neutrophils in particular. The peptide is located in the Fd fragment of the gamma-globulin molecule.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.