HSDB 3453
\ˌe͡ɪt͡ʃˌɛsdˌiːbˈiː θɹˈiː θˈa͡ʊzənd fˈɔːhˈʌndɹədən fˈɪftiθɹˈiː], \ˌeɪtʃˌɛsdˌiːbˈiː θɹˈiː θˈaʊzənd fˈɔːhˈʌndɹədən fˈɪftiθɹˈiː], \ˌeɪ_tʃ_ˌɛ_s_d_ˌiː_b_ˈiː θ_ɹ_ˈiː θ_ˈaʊ_z_ə_n_d f_ˈɔː_h_ˈʌ_n_d_ɹ_ə_d_ə_n f_ˈɪ_f_t_i_θ_ɹ_ˈiː]\
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A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.
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Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.