HER 2 PROTO ONCOGENE PROTEIN
\hɜː tˈuː pɹˈə͡ʊtə͡ʊ ˈɒnkə͡ʊd͡ʒˌiːn pɹˈə͡ʊtiːn], \hɜː tˈuː pɹˈəʊtəʊ ˈɒnkəʊdʒˌiːn pɹˈəʊtiːn], \h_ɜː t_ˈuː p_ɹ_ˈəʊ_t_əʊ ˈɒ_n_k_əʊ_dʒ_ˌiː_n p_ɹ_ˈəʊ_t_iː_n]\
Definitions of HER 2 PROTO ONCOGENE PROTEIN
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A cell surface protein-tyrosine kinase receptor that is found to be overexpressed in a significant number of adenocarcinomas. It has extensive homology to and can heterodimerize with the EGF receptor (RECEPTOR, EPIDERMAL GROWTH FACTOR), the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Activation of the erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB receptor family members. EC 2.7.11.-.
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