\hɜː tˈuː d͡ʒˈiːnz], \hɜː tˈuː dʒˈiːnz], \h_ɜː t_ˈuː dʒ_ˈiː_n_z]\
Definitions of HER2 GENES
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The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (RECEPTOR, ERBB-2), a protein with structural features simular to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythoblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2.
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