GENERALIZED MYASTHENIA GRAVIS
\d͡ʒˈɛnəɹə͡lˌa͡ɪzd mˌa͡ɪɐsθˈiːni͡ə ɡɹˈavɪs], \dʒˈɛnəɹəlˌaɪzd mˌaɪɐsθˈiːniə ɡɹˈavɪs], \dʒ_ˈɛ_n_ə_ɹ_əl_ˌaɪ_z_d m_ˌaɪ__ɐ_s_θ_ˈiː_n_iə ɡ_ɹ_ˈa_v_ɪ_s]\
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A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed against acetylcholine receptors damage the motor endplate portion of the NEUROMUSCULAR JUNCTION, impairing the transmission of impulses to skeletal muscles. Clinical manifestations may include diplopia, ptosis, and weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles. THYMOMA is commonly associated with this condition. (Adams et al., Principles of Neurology, 6th ed, p1459)
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Word of the day
Snake's-head
- Guinea-hen flower; -- so called in England because its spotted petals resemble the scales of a snake's head.