GENE AMPLIFICATION
\d͡ʒˈiːn ˌamplɪfɪkˈe͡ɪʃən], \dʒˈiːn ˌamplɪfɪkˈeɪʃən], \dʒ_ˈiː_n ˌa_m_p_l_ɪ_f_ɪ_k_ˈeɪ_ʃ_ə_n]\
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A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
By DataStellar Co., Ltd