EUKARYOTIC TOPOISOMERASE I
\jˌuːkɐɹɪˈɒtɪk tˈɒpɔ͡ɪsˌə͡ʊmɹe͡ɪz ˈa͡ɪ], \jˌuːkɐɹɪˈɒtɪk tˈɒpɔɪsˌəʊmɹeɪz ˈaɪ], \j_ˌuː_k_ɐ_ɹ_ɪ__ˈɒ_t_ɪ_k t_ˈɒ_p_ɔɪ_s_ˌəʊ_m_ɹ_eɪ_z ˈaɪ]\
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Eukaryotic enzymes of the DNA TOPOISOMERASES TYPE I class that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These eukaryotic enzymes reduce the topological stress in the DNA structure by relaxing both negatively and positively supercoiled DNA.
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.