DNA FOOTPRINTS
\dˌiːˌɛnˈe͡ɪ fˈʊtpɹɪnts], \dˌiːˌɛnˈeɪ fˈʊtpɹɪnts], \d_ˌiː__ˌɛ_n_ˈeɪ f_ˈʊ_t_p_ɹ_ɪ_n_t_s]\
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A method for determining the sequence specificity of DNA-binding proteins. DNA footprinting utilizes a DNA damaging agent (either a chemical reagent or a nuclease) which cleaves DNA at every base pair. DNA cleavage is inhibited where the ligand binds to DNA. (from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
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Word of the day
Mustagh Range
- a mountain range in northern Kashmir; an extension of the Hindu Kush; contains 2nd highest peak