DNA FOOTPRINT
\dˌiːˌɛnˈe͡ɪ fˈʊtpɹɪnt], \dˌiːˌɛnˈeɪ fˈʊtpɹɪnt], \d_ˌiː__ˌɛ_n_ˈeɪ f_ˈʊ_t_p_ɹ_ɪ_n_t]\
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A method for determining the sequence specificity of DNA-binding proteins. DNA footprinting utilizes a DNA damaging agent (either a chemical reagent or a nuclease) which cleaves DNA at every base pair. DNA cleavage is inhibited where the ligand binds to DNA. (from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
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Word of the day
Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.