DNA FOOTPRINTING
\dˌiːˌɛnˈe͡ɪ fˈʊtpɹɪntɪŋ], \dˌiːˌɛnˈeɪ fˈʊtpɹɪntɪŋ], \d_ˌiː__ˌɛ_n_ˈeɪ f_ˈʊ_t_p_ɹ_ɪ_n_t_ɪ_ŋ]\
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A method for determining the sequence specificity of DNA-binding proteins. DNA footprinting utilizes a DNA damaging agent (either a chemical reagent or a nuclease) which cleaves DNA at every base pair. DNA cleavage is inhibited where the ligand binds to DNA. (from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
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