CYTOTOXIC T LYMPHOCYTE
\sˌa͡ɪtətˈɒksɪk tˈiː lˈɪmfəsˌa͡ɪt], \sˌaɪtətˈɒksɪk tˈiː lˈɪmfəsˌaɪt], \s_ˌaɪ_t_ə_t_ˈɒ_k_s_ɪ_k t_ˈiː l_ˈɪ_m_f_ə_s_ˌaɪ_t]\
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Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from natural killer cells (KILLER CELLS, NATURAL) and from KILLER CELLS mediating antibody-dependent cell cytotoxicity. There are two effector phenotypes: TC1 and TC2.
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.