CORTICAL LEWY BODY DISEASE
\kˈɔːtɪkə͡l lˈuːi bˈɒdi dɪzˈiːz], \kˈɔːtɪkəl lˈuːi bˈɒdi dɪzˈiːz], \k_ˈɔː_t_ɪ_k_əl l_ˈuː_i b_ˈɒ_d_i d_ɪ_z_ˈiː_z]\
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A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124)
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