CAROTID ARTERY PLAQUE
\kəɹˈɒtɪd ˈɑːtəɹi plˈak], \kəɹˈɒtɪd ˈɑːtəɹi plˈak], \k_ə_ɹ_ˈɒ_t_ɪ_d ˈɑː_t_ə_ɹ_i p_l_ˈa_k]\
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Narrowing or stricture of the internal, common, or external carotid artery, most often as a result of atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce thrombus formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a transient ischemic attack (ISCHEMIC ATTACK, TRANSIENT) or CEREBROVASCULAR ACCIDENT. Emboli which travel to the eye may manifest as AMAUROSIS FUGAX (temporary blindness). (From Adams et al., Principles of Neurology, 6th ed, pp822-3)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.