Definitions of c rel Proteins

  1. Cellular DNA- binding proteins encoded by the rel gene ( GENES, REL). They are expressed predominately in hematopoietic cells and may play a role in lymphocyte differentiation. Rel frequently combines with other related proteins ( NF- KAPPA B, I- kappa B, relA) to form heterodimers that regulate transcription. Rearrangement or overexpression of c- rel can cause tumorigenesis.