ANTIRHEUMATIC AGENTS, NON STEROIDAL
\ˌantɪɹuːmˈatɪk ˈe͡ɪd͡ʒənts], \ˌantɪɹuːmˈatɪk ˈeɪdʒənts], \ˌa_n_t_ɪ_ɹ_uː_m_ˈa_t_ɪ_k ˈeɪ_dʒ_ə_n_t_s]\
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Anti-inflammatory agents that are not steroids. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They are used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. Certain NSAIDs also may inhibit lipoxygenase enzymes or phospholipase C or may modulate T-cell function. (AMA Drug Evaluations Annual, 1994, p 1814-5)
By DataStellar Co., Ltd
Nearby Words
- antirenter
- antirevolutionary
- antirhachitic
- antirheumatic
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- Antirheumatic Agents, Non Steroidal
- antirheumatic drugs
- antirheumatin
- antirhinum acutangulum
- antirhinum elatine
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