ACTIVATED PARTIAL THROMBOPLASTIN TIME
\ˈaktɪvˌe͡ɪtɪd pˈɑːʃə͡l θɹˈɒmbəplˌastɪn tˈa͡ɪm], \ˈaktɪvˌeɪtɪd pˈɑːʃəl θɹˈɒmbəplˌastɪn tˈaɪm], \ˈa_k_t_ɪ_v_ˌeɪ_t_ɪ_d p_ˈɑː_ʃ_əl θ_ɹ_ˈɒ_m_b_ə_p_l_ˌa_s_t_ɪ_n t_ˈaɪ_m]\
Definitions of ACTIVATED PARTIAL THROMBOPLASTIN TIME
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Test of the intrinsic (factors VIII, IX, XI, and XII) and common (fibrinogen, prothrombin, factors V and X) pathways of coagulation in which a mixture of plasma and phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides) is recalcified and the time required for the appearance of fibrin strands measured. Activation may be provided by contact with the glass tube or exposure to activators (e.g., ellagic acid, particulate silicates such as diatomaceous earth or kaolin) before addition of the calcium chloride. It is used as a screening test and to monitor heparin therapy.
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