ABNORMAL VARIATION

\ɐbnˈɔːmə͡l vˌe͡əɹɪˈe͡ɪʃən], \ɐbnˈɔːmə‍l vˌe‍əɹɪˈe‍ɪʃən], \ɐ_b_n_ˈɔː_m_əl v_ˌeə_ɹ_ɪ__ˈeɪ_ʃ_ə_n]\

Definitions of ABNORMAL VARIATION

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1910 - Black's Law Dictionary (2nd edition)
By Henry Campbell Black

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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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