ABNORMALITIES, CONGENITAL, NERVOUS SYSTEM

\ɐbnɔːmˈalɪtiz], \ɐbnɔːmˈalɪtiz], \ɐ_b_n_ɔː_m_ˈa_l_ɪ_t_i_z]\

Definitions of ABNORMALITIES, CONGENITAL, NERVOUS SYSTEM

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2010 - Medical Dictionary Database
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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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