7,8 DIHYDRONEOPTERINTRIPHOSPHATE SYNTHETASE
\sˈɛvən ˈe͡ɪt da͡ɪhˈa͡ɪdɹə͡ʊnˌɒptəɹˌɪntɹɪfˌɒsfe͡ɪt sˈɪnθɪtˌe͡ɪs], \sˈɛvən ˈeɪt daɪhˈaɪdɹəʊnˌɒptəɹˌɪntɹɪfˌɒsfeɪt sˈɪnθɪtˌeɪs], \s_ˈɛ_v_ə_n ˈeɪ_t d_aɪ_h_ˈaɪ_d_ɹ_əʊ_n_ˌɒ_p_t_ə_ɹ_ˌɪ_n_t_ɹ_ɪ_f_ˌɒ_s_f_eɪ_t s_ˈɪ_n_θ_ɪ_t_ˌeɪ_s]\
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(GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).
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