5 AMINOLEVULINATE SYNTHETASE
\fˈa͡ɪv ɐmˌɪnə͡ʊlvjˈʊlɪnˌe͡ɪt sˈɪnθɪtˌe͡ɪs], \fˈaɪv ɐmˌɪnəʊlvjˈʊlɪnˌeɪt sˈɪnθɪtˌeɪs], \f_ˈaɪ_v ɐ_m_ˌɪ_n_əʊ_l_v_j_ˈʊ_l_ɪ_n_ˌeɪ_t s_ˈɪ_n_θ_ɪ_t_ˌeɪ_s]\
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An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyl phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis and, in liver at least, is feedback inhibited by heme. (Dorland, 28th ed) EC 2.3.1.37.
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