\ˌɛsˈe͡ɪt͡ʃwˈɔːtsmən fɪnˈɒmɪnən], \ˌɛsˈeɪtʃwˈɔːtsmən fɪnˈɒmɪnən], \ˌɛ_s_ˈeɪ_tʃ_w_ˈɔː_t_s_m_ə_n f_ɪ_n_ˈɒ_m_ɪ_n_ə_n]\
Definitions of SHWARTZMAN PHENOMENON
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A vasculitis, local or systemic, caused by a two-stage reaction in which a first encounter with endotoxin produces intravascular fibrin thrombi whose clearance results in reticuloendothelial blockade which prevents the clearance of thrombi caused by a second encounter with endotoxin, (or a variety of polyanions, glycogen or antigen/antibody complexes) resulting in tissue necrosis and/or hemorrhage. In pregnancy gram-negative septicemia during delivery or abortion may serve as the first or provocative encounter.
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