LYMPHOCYTE ACTIVATION
\lˈɪmfəsˌa͡ɪt ˌaktɪvˈe͡ɪʃən], \lˈɪmfəsˌaɪt ˌaktɪvˈeɪʃən], \l_ˈɪ_m_f_ə_s_ˌaɪ_t ˌa_k_t_ɪ_v_ˈeɪ_ʃ_ə_n]\
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Morphologic alteration of small lymphocytes in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by interleukins, mitogens such as phytohemagglutinins, and by specific antigens. It may also occur in vivo, as in graft rejection and chronic myelogenous leukemia.
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.