GRANVILLE PENN

\ɡɹˈanvɪl pˈɛn], \ɡɹˈanvɪl pˈɛn], \ɡ_ɹ_ˈa_n_v_ɪ_l p_ˈɛ_n]\
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1910 - Warner's dictionary of authors ancient and modern
By Charles Dudley Warner

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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