\kɹˈʌʃ sˈɪndɹə͡ʊm], \kɹˈʌʃ sˈɪndɹəʊm], \k_ɹ_ˈʌ_ʃ s_ˈɪ_n_d_ɹ_əʊ_m]\
Definitions of CRUSH SYNDROME
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Severe systemic manifestation of trauma and ischemia involving soft tissues, principally skeletal muscle, due to prolonged severe crushing. It leads to increased permeability of the cell membrane and to the release of potassium, enzymes, and myoglobin from within cells. Ischemic renal dysfunction secondary to hypotension and diminished renal perfusion results in acute tubular necrosis and uremia.
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