CIS DICHLORODIAMMINEPLATINUM(II)
\sˈɪs dˈɪklˌɔːɹə͡ʊdˌi͡əma͡ɪnplˌatɪnəm ɹˌə͡ʊmən tˈuː], \sˈɪs dˈɪklˌɔːɹəʊdˌiəmaɪnplˌatɪnəm ɹˌəʊmən tˈuː], \s_ˈɪ_s d_ˈɪ_k_l_ˌɔː_ɹ_əʊ_d_ˌiə_m_aɪ_n_p_l_ˌa_t_ɪ_n_ə_m__ ɹ_ˌəʊ_m_ə_n_ t_ˈuː]\
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An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
By DataStellar Co., Ltd
