CIS DIAMMINEDICHLOROPLATINUM
\sˈɪs dˈa͡ɪəmˌa͡ɪndɪklˌɔːɹə͡ʊplˌatɪnəm], \sˈɪs dˈaɪəmˌaɪndɪklˌɔːɹəʊplˌatɪnəm], \s_ˈɪ_s d_ˈaɪ_ə_m_ˌaɪ_n_d_ɪ_k_l_ˌɔː_ɹ_əʊ_p_l_ˌa_t_ɪ_n_ə_m]\
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An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
By DataStellar Co., Ltd
Word of the day
tinctura quininae ammoniata
- A preparation made by dissolving quinin sulphate in alcohol [Br. Ph.].