CILASTATIN
\sˈɪlastˌatɪn], \sˈɪlastˌatɪn], \s_ˈɪ_l_a_s_t_ˌa_t_ɪ_n]\
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A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukeotriene E4.
By DataStellar Co., Ltd
