CILASTATIN MONOSODIUM SALT
\sˈɪlastˌatɪn mˌɒnə͡ʊsˈə͡ʊdi͡əm sˈɒlt], \sˈɪlastˌatɪn mˌɒnəʊsˈəʊdiəm sˈɒlt], \s_ˈɪ_l_a_s_t_ˌa_t_ɪ_n m_ˌɒ_n_əʊ_s_ˈəʊ_d_iə_m s_ˈɒ_l_t]\
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A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukeotriene E4.
By DataStellar Co., Ltd
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