\kˈə͡ʊlɹe͡ɪd͡ʒən], \kˈəʊlɹeɪdʒən], \k_ˈəʊ_l_ɹ_eɪ_dʒ_ə_n]\
Definitions of CHOLERAGEN
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The enterotoxin from Vibrio cholerae. It is a protein that consists of two major components, the heavy (H) or A peptide and the light (L) or B peptide or choleragenoid. The B peptide anchors the protein to intestinal epithelial cells, while the A peptide, enters the cytoplasm, and activates adenylate cyclase, and production of cAMP. Increased levels of cAMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
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