ANTENATAL MYASTHENIA GRAVIS
\ˈantənˌe͡ɪtə͡l mˌa͡ɪɐsθˈiːni͡ə ɡɹˈavɪs], \ˈantənˌeɪtəl mˌaɪɐsθˈiːniə ɡɹˈavɪs], \ˈa_n_t_ə_n_ˌeɪ_t_əl m_ˌaɪ__ɐ_s_θ_ˈiː_n_iə ɡ_ɹ_ˈa_v_ɪ_s]\
Definitions of ANTENATAL MYASTHENIA GRAVIS
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A disorder of neuromuscular transmission that occurs in a minority of newborns born to women with myasthenia gravis. Clinical features are usually present at birth or develop in the first 3 days of life and consist of hypotonia and impaired respiratory, suck, and swallowing abilities. This condition is associated with the passive transfer of acetylcholine receptor antibodies through the placenta. In the majority of infants the myasthenic weakness resolves (i.e., transient neonatal myasthenia gravis) although this disorder may rarely continue beyond the neonatal period (i.e., persistent neonatal myasthenia gravis). (From Menkes, Textbook of Child Neurology, 5th ed, p823; Neurology 1997 Jan;48 (1):50-4)
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