Definitions of v K ras Oncogenes
Family of retrovirus- associated DNA sequences ( ras) originally isolated from Harvey ( H- ras, Ha- ras, rasH) and Kirsten ( K- ras, Ki- ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H- ras and K- ras genes have been detected in human, avian, murine, and non- vertebrate genomes. The closely related N- ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon- intron structure and each encodes a p21 protein.