SEZARY SYNDROME
\sˈɛzəɹi sˈɪndɹə͡ʊm], \sˈɛzəɹi sˈɪndɹəʊm], \s_ˈɛ_z_ə_ɹ_i s_ˈɪ_n_d_ɹ_əʊ_m]\
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A form of cutaneous T-cell lymphoma manifested by generalized exfoliative erythroderma, intense pruritus, peripheral lymphadenopathy, and abnormal hyperchromatic mononuclear cells in the skin, lymph nodes, and peripheral blood (Sezary cells). (Dorland, 27th ed)
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Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.