PYRROLINE CARBOXYLATE REDUCTASES
\pˈɪɹəlˌiːn kˈɑːbəksˌɪle͡ɪt ɹɪdˈʌkte͡ɪsɪz], \pˈɪɹəlˌiːn kˈɑːbəksˌɪleɪt ɹɪdˈʌkteɪsɪz], \p_ˈɪ_ɹ_ə_l_ˌiː_n k_ˈɑː_b_ə_k_s_ˌɪ_l_eɪ_t ɹ_ɪ_d_ˈʌ_k_t_eɪ_s_ɪ_z]\
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A group of enzymes that catalyze the reduction of 1-pyrroline carboxylate to proline in the presence of NAD (P)H. Includes both the 2-oxidoreductase (EC 1.5.1.1) and the 5-oxidoreductase (EC 1.5.1.2). The former also reduces 1-piperidine-2-carboxylate to pipecolate and the latter also reduces 1-pyrroline-3-hydroxy-5-carboxylate to hydroxyproline.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.