PRIMITIVE BUNDLE

\pɹˈɪmɪtˌɪv bˈʌndə͡l], \pɹˈɪmɪtˌɪv bˈʌndə‍l], \p_ɹ_ˈɪ_m_ɪ_t_ˌɪ_v b_ˈʌ_n_d_əl]\

Definitions of PRIMITIVE BUNDLE

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1916 - Appleton's medical dictionary
By Smith Ely Jelliffe

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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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