POLYAROMATIC HYDROCARBON RECEPTOR
\pˌɒlɪɐɹə͡ʊmˈatɪk hˈa͡ɪdɹəkˌɑːbən ɹɪsˈɛptə], \pˌɒlɪɐɹəʊmˈatɪk hˈaɪdɹəkˌɑːbən ɹɪsˈɛptə], \p_ˌɒ_l_ɪ__ɐ_ɹ_əʊ_m_ˈa_t_ɪ_k h_ˈaɪ_d_ɹ_ə_k_ˌɑː_b_ə_n ɹ_ɪ_s_ˈɛ_p_t_ə]\
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Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.
By DataStellar Co., Ltd
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Nearby Words
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- Polyaromatic Hydrocarbon Receptor
- polyaromatic hydrocarbon receptors
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