PI 3K
\pˈa͡ɪ θɹˈiː kˈe͡ɪ], \pˈaɪ θɹˈiː kˈeɪ], \p_ˈaɪ θ_ɹ_ˈiː k_ˈeɪ]\
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An enzyme that catalyzes the conversion of phosphatidylinositol to phosphatidylinositol 3-phosphate. This is the first committed step in the biosynthesis of phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. This pathway is thought to play a critical role in DNA repair, V (D)J recombination and cell cycle checkpoints. EC 2.7.1.137.
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