OXIDATIVE STRESSES
\ˈɒksɪdətˌɪv stɹˈɛsɪz], \ˈɒksɪdətˌɪv stɹˈɛsɪz], \ˈɒ_k_s_ɪ_d_ə_t_ˌɪ_v s_t_ɹ_ˈɛ_s_ɪ_z]\
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A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
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Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.