MUCOLIPIDOSIS II
\mjˌuːkəlˌɪpɪdˈə͡ʊsɪs ɹˌə͡ʊmən tˈuː], \mjˌuːkəlˌɪpɪdˈəʊsɪs ɹˌəʊmən tˈuː], \m_j_ˌuː_k_ə_l_ˌɪ_p_ɪ_d_ˈəʊ_s_ɪ_s ɹ_ˌəʊ_m_ə_n_ t_ˈuː]\
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A group of inherited metabolic diseases characterized by the accumulation of excessive amounts of acid mucopolysaccharides, sphingolipids, and/or glycolipids in visceral and mesenchymal cells. Abnormal amounts of sphingolipids or glycolipids are present in neural tissue. Mental retardation and skeletal changes, most notably dysostosis multiplex, occur frequently. (From Joynt, Clinical Neurology, 1992, Ch56, pp36-7)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.