MELKERSSON SYNDROME
\mˈɛlkəsən sˈɪndɹə͡ʊm], \mˈɛlkəsən sˈɪndɹəʊm], \m_ˈɛ_l_k_ə_s_ə_n s_ˈɪ_n_d_ɹ_əʊ_m]\
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An idiopathic syndrome characterized by one or more of the following; recurrent orofacial swelling, relapsing facial paralysis, and fissured tongue (lingua plicata). The onset is usually in childhood and relapses are common. Cheilitis granulomatosa is a monosymptomatic variant of this condition. (Dermatol Clin 1996 Apr;14 (2):371-9; Magalini & Magalini, Dictionary of Medical Syndromes, 4th ed, p531)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.