INBRED CFTR MOUSE
\ˈɪnbɹɛd sˌiːˌɛftˌiːˈɑː mˈa͡ʊs], \ˈɪnbɹɛd sˌiːˌɛftˌiːˈɑː mˈaʊs], \ˈɪ_n_b_ɹ_ɛ_d s_ˌiː__ˌɛ_f_t_ˌiː__ˈɑː m_ˈaʊ_s]\
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A strain of mice widely studied as a model for cystic fibrosis. These mice are generated from embryonic stem cells in which the CFTR (cystic fibrosis transmembrane conductance regulator) gene is inactivated by gene targeting. As a result, all mice have one copy of this altered gene in all their tissues. Mice homozygous for the disrupted gene exhibit many features common to young cystic fibrosis patients, including failure to thrive, meconium ileus, and alteration of mucous and serous glands.
By DataStellar Co., Ltd
Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.