HTH MOTIF
\ˌe͡ɪt͡ʃtˌiːˈe͡ɪt͡ʃ mə͡ʊtˈiːf], \ˌeɪtʃtˌiːˈeɪtʃ məʊtˈiːf], \ˌeɪ_tʃ_t_ˌiː__ˈeɪ_tʃ m_əʊ_t_ˈiː_f]\
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The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were originally identified in bacterial proteins but have since been found in hundreds of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the "turn." The two helices are held at a fixed angle, primarily through interactions between the two helices. (From Alberts et al., Molecular Biology of the Cell, 3d ed, p408-9)
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