HERPES SIMPLEX ENCEPHALITIDES
\hˈɜːpiːz sˈɪmplɛks ɛnsˈɛfɐlˌɪta͡ɪdz], \hˈɜːpiːz sˈɪmplɛks ɛnsˈɛfɐlˌɪtaɪdz], \h_ˈɜː_p_iː_z s_ˈɪ_m_p_l_ɛ_k_s ɛ_n_s_ˈɛ_f_ɐ_l_ˌɪ_t_aɪ_d_z]\
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An acute (or rarely chronic) inflammatory process of the brain caused by SIMPLEXVIRUS infections which may be fatal. The majority of infections are caused by human herpesvirus 1 (HERPESVIRUS 1, HUMAN) and less often by human herpesvirus 2 (HERPESVIRUS 2, HUMAN). Clinical manifestations include FEVER; HEADACHE; SEIZURES; HALLUCINATIONS; behavioral alterations; APHASIA; hemiparesis; and COMA. Pathologically, the condition is marked by a hemorrhagic necrosis involving the medial and inferior TEMPORAL LOBE and orbital regions of the FRONTAL LOBE. (From Adams et al., Principles of Neurology, 6th ed, pp751-4)
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