GP120(V FMS)
\d͡ʒˌiːpˈiː wˈɒnhˈʌndɹədən twˈɛnti vˈiː ˌɛfˌɛmˈɛs], \dʒˌiːpˈiː wˈɒnhˈʌndɹədən twˈɛnti vˈiː ˌɛfˌɛmˈɛs], \dʒ_ˌiː_p_ˈiː w_ˈɒ_n_h_ˈʌ_n_d_ɹ_ə_d_ə_n t_w_ˈɛ_n_t_i__ v_ˈiː_ ˌɛ_f_ˌɛ_m_ˈɛ_s]\
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Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120 (v-fms) is post-translationally modified to generate gp140 (v-fms).
By DataStellar Co., Ltd
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