EXPERIMENTAL AUTOIMMUNE NEURITIS
\ɛkspˌɛɹɪmˈɛntə͡l ˌɔːtə͡ʊɪmjˈuːn njuːɹˈa͡ɪtɪs], \ɛkspˌɛɹɪmˈɛntəl ˌɔːtəʊɪmjˈuːn njuːɹˈaɪtɪs], \ɛ_k_s_p_ˌɛ_ɹ_ɪ_m_ˈɛ_n_t_əl ˌɔː_t_əʊ_ɪ_m_j_ˈuː_n n_j_uː_ɹ_ˈaɪ_t_ɪ_s]\
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An experimental animal demyelinating disease model of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84 (1):40-52)
By DataStellar Co., Ltd
Nearby Words
- experimental allergic neuritis
- experimental animal model
- experimental animal models
- experimental autoimmune myositis
- experimental autoimmune neuritides
- Experimental Autoimmune Neuritis
- experimental autoimmune neuropathies
- experimental autoimmune neuropathy
- experimental condition
- experimental design
- experimental designs