ESTROGEN SYNTHETASE
\ˈɛstɹəd͡ʒən sˈɪnθɪtˌe͡ɪs], \ˈɛstɹədʒən sˈɪnθɪtˌeɪs], \ˈɛ_s_t_ɹ_ə_dʒ_ə_n s_ˈɪ_n_θ_ɪ_t_ˌeɪ_s]\
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An enzyme which converts androgens to estrogens by desaturating ring A of the steroid. This enzyme complex is located in the endoplasmic reticulum of estrogen-producing cells including ovaries, placenta, testicular Sertoli and Leydig cells, adipose, and brain tissues. The enzyme complex has two components, one of which is the CYP19 gene product, the aromatase cytochrome P-450. The other component is NADPH-cytochrome P-450 reductase which transfers reducing equivalents to P-450 (arom). EC 1.14.13.-.
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