ERK MAP KINASES
\ˈɜːk mˈap kˈɪne͡ɪsɪz], \ˈɜːk mˈap kˈɪneɪsɪz], \ˈɜː_k m_ˈa_p k_ˈɪ_n_eɪ_s_ɪ_z]\
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A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES). Families of these mitogen-activated protein kinases (MAPKs) include extracellular signal-regulated kinases (ERKs), stress-activated protein kinases (SAPKs) (also known as c-jun terminal kinases (JNKs)), and p38-mitogen-activated protein kinases. EC 2,7,1.-
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