EPITHELIOID CELLS
\ˈɛpɪθˌɛlɪˌɔ͡ɪd sˈɛlz], \ˈɛpɪθˌɛlɪˌɔɪd sˈɛlz], \ˈɛ_p_ɪ_θ_ˌɛ_l_ɪ__ˌɔɪ_d s_ˈɛ_l_z]\
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Characteristic cells of granulomatous hypersensitivity. They appear as large, flattened cells with increased endoplasmic reticulum. They are believed to be activated macrophages that have differentiated as a result of prolonged antigenic stimulation. Further differentiation or fusion of epithelioid cells is thought to produce multinucleated giant cells (GIANT CELLS).
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.